Opioid-Induced Pain: When is it Present? (742)

Opioid-induced hyperalgesia: pain hurts?

In the current issue of the British Journal of Anaesthesia, Shin and colleagues report that propofol used for the maintenance of general anaesthesia may prevent remifentanilinduced hyperalgesia. In their study, a comparison of propofol and sevoflurane combined with either high dose or low dose of remifentanil for the maintenance of general anaesthesia in breast cancer surgery was conducted. The...

When Is It Coevolution?

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Schistosomal glomerulonephritis: is it more prevalent in hepatosplenic patients when cor pulmonale is present?

S. mansoni infection can produce damage in several organs, in some due to immunological altera­ tions such as the development of glomerulopathy2 and in others, at least in great part, due to vascular obstruction related to egg deposition, such as chronic cor pulmonale 1. Both situations are essentially obser­ ved in patients with the hepatosplenic form of the parasitic infection. There are repo...

Opioid Receptors in Pain Management: Past, Present and Future

Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?

Opiates are the primary treatment for pain management in cancer patients reporting moderate to severe pain, and are being increasingly used for non-cancer chronic pain. However, prolonged administration of opiates is associated with significant problems including the development of antinociceptive tolerance, wherein higher doses of the drug are required over time to elicit the same amount of an...